Why the study?
Oxidative stress plays a fundamental role in vascular dysfunction and disorders, making sources of reactive oxygen species prime targets for therapeutic development.
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Design
Review
Oxidative stress inhibition strategies merit targeted trials in vascular disease; leaves open whether they improve clinical outcomes.
Oxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production.
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Sena et al. (2018) studied this question.
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