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May guide earlier cognitive surveillance; leaves open whether midlife interventions alter APOE-related trajectories.
APOE epsilon4 is associated with greater cognitive decline in middle-aged Caucasian individuals, with a reduced decline among epsilon2 carriers. This suggests that the processes by which APOE genotype mediates dementia risk are operative well in advance of overt dementia.
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Blair et al. (2005) studied this question.
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