Do inhaled prostacyclin and inhaled milrinone have additive pulmonary vasodilatory effects without systemic effects in postcardiac surgical patients with pulmonary hypertension?
Inhaled prostacyclin and milrinone can induce selective pulmonary vasodilation without causing systemic hypotension in postcardiac surgical patients with pulmonary hypertension.
Pulmonary hypertension may cause or aggravate right heart failure. IV vasodilators reduce systemic blood pressure and might thereby further impair coronary perfusion and right heart performance. In the present study of cardiac surgical patients with pulmonary hypertension, selective pulmonary vasodilation without systemic effects was induced by nebulized, inhaled vasodilators.
Haraldsson et al. (Sat,) studied this question.