Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials

Paul E. Sax; Kristine M. Erlandson; Jordan E. Lake; Grace A. McComsey; Chloe Orkin; Stefan Eßer; Todd T. Brown; Jürgen K. Rockstroh; Xuelian Wei; Christoph C Carter; Lijie Zhong; Diana M. Brainard; Kathleen Melbourne; Moupali Das; Hans-Jürgen Stellbrink; Frank A. Post; Laura Waters; John R. Koethe

doi:10.1093/cid/ciz999

Key Points

To evaluate the risk factors, determinants, and potential mechanisms driving weight gain after the initiation of antiretroviral therapy in clinical trials.
Review and synthesis of randomized comparative clinical trials evaluating weight changes following the start of antiretroviral therapy.
Evaluation of demographic characteristics, HIV-specific clinical markers, and distinct antiretroviral drug combinations as contributing variables.
Weight gain occurs ubiquitously across clinical trials following the initiation of antiretroviral therapy.
Increases in weight are multifactorial, driven by interactions among patient demographics, baseline HIV-related disease factors, and specific antiretroviral drug choices, though the precise biological mechanisms remain unknown.

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Implication

Randomized trials reveal multifactorial risk factors for weight gain during antiretroviral therapy initiation, highlighting complex interactions between demographics, HIV status, and drug regimens.

Abstract

Weight gain is ubiquitous in clinical trials of ART initiation and is multifactorial in nature, with demographic factors, HIV-related factors, and the composition of ART regimens as contributors. The mechanisms by which certain ART agents differentially contribute to weight gain are unknown.

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Sax et al. (2019) studied this question.

synapsesocial.com/papers/69debf531d9bba5129b0cc0c https://doi.org/10.1093/cid/ciz999

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Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials

Key Points

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Implication

Abstract

Discussion

Cite This Study

Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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