What question did this study set out to answer?

To identify the physiological endogenous ligand for the orphan nicotinic acid receptor PUMA-G/HM74a and characterize its role in regulating adipocyte lipolysis.

June 2, 2005Journal of Biological ChemistryOpen Access

(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G

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Authors

ATAndrew K.P. TaggartNovartis (Switzerland)JKJukka KeroUniversity of Turku XGXiaodong GanHainan University

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Implication

Preclinical study demonstrates that (D)-beta-hydroxybutyrate inhibits adipocyte lipolysis via PUMA-G in mice, suggesting a homeostatic feedback loop to prevent ketoacidosis during starvation.

Key Points

To identify the physiological endogenous ligand for the orphan nicotinic acid receptor PUMA-G/HM74a and characterize its role in regulating adipocyte lipolysis.
Evaluated receptor activation of mouse PUMA-G and human HM74a by the ketone body (D)-beta-hydroxybutyrate at physiological fasting serum concentrations.
Assessed the inhibition of lipolysis in mouse adipocytes in the presence of (D)-beta-hydroxybutyrate to determine PUMA-G dependency.
(D)-beta-hydroxybutyrate specifically activates both mouse PUMA-G and human HM74a at concentrations typically observed in fasting serum.
(D)-beta-hydroxybutyrate suppresses mouse adipocyte lipolysis in a PUMA-G-dependent manner, establishing it as the first known endogenous ligand for this receptor.

Cite This Study

Taggart et al. (2005) studied this question.

synapsesocial.com/papers/69debfb1499d77a496b0cbb1 https://doi.org/10.1074/jbc.c500213200

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Implication

Preclinical study demonstrates that (D)-beta-hydroxybutyrate inhibits adipocyte lipolysis via PUMA-G in mice, suggesting a homeostatic feedback loop to prevent ketoacidosis during starvation.

(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G

Discussion

Member takes

Implication

Key Points

Cite This Study

(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G

Discussion

Member takes

Implication

Key Points

Cite This Study

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