A new, economical, and efficient process has been developed for large‐scale synthesis of donepezil 1, an anti‐Alzheimer's drug. The process involves palladium‐catalyzed hydrogenation of (2E)‐5,6‐dimethoxy‐2‐(pyridin‐4‐ylmethylene)indan‐1‐one 6 to provide 5,6‐dimethoxy‐2‐(piperidin‐4‐ylmethyl)indan‐1‐one 8 as a key step.
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Elati et al. (2006) studied this question.
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