Population
Mouse gene knockout model (STAT5b-/- mice and wild-type mice)
Comparison
STAT5b gene disruption vs Wild-type mice
Design
Preclinical
Authors
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Cautions against direct human extrapolation from mouse data; extends mechanistic insight into GH-mediated sexual dimorphism.
STAT5b is required to maintain sexual dimorphism of body growth rates and liver gene expression, mediating the sexually dimorphic effects of GH pulses.
Udy et al. (1997) studied this question.
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