What question did this study set out to answer?

To review the molecular foundations of CD28 family receptor signaling and evaluate how these receptors modulate T-cell activation and influence immune-mediated diseases.

January 20, 2024International Journal of Molecular SciencesOpen Access

The Role of the CD28 Family Receptors in T-Cell Immunomodulation

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To review the molecular foundations of CD28 family receptor signaling and evaluate how these receptors modulate T-cell activation and influence immune-mediated diseases.
Synthesized molecular and functional literature on CD28 receptor family members and their interactions with B7 family ligands.
Characterized the comparative biological roles of activating versus inhibitory immune checkpoint receptors in adaptive immune regulation.
CD28 and ICOS function as positive co-stimulatory receptors that enhance T-cell activity, proliferation, and adaptive immune responses.
CTLA-4, PD-1, and BTLA act as co-inhibitory receptors that suppress T-cell activation upon binding to their respective B7 family ligands.
Crosstalk and signaling balance between these opposing receptor pathways determine the trajectory of immune responses and drive susceptibility to immune-related pathologies.

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Implication

Review uncovers CD28 family receptor signaling mechanisms in T cells, highlighting their central role in adaptive immunity and immune-related diseases.

Cite This Study

Ciesielska-Figlon et al. (2024) studied this question.

synapsesocial.com/papers/69dec5644838c5c0bab0cf1f https://doi.org/10.3390/ijms25021274

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Implication

Review uncovers CD28 family receptor signaling mechanisms in T cells, highlighting their central role in adaptive immunity and immune-related diseases.

The Role of the CD28 Family Receptors in T-Cell Immunomodulation

Key Points

Discussion

Implication

Cite This Study

The Role of the CD28 Family Receptors in T-Cell Immunomodulation

Key Points

Discussion

Implication

Cite This Study

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