December 29, 2003Proceedings of the National Academy of SciencesOpen Access

Demonstration of mammalian protein O -mannosyltransferase activity: Coexpression of POMT1 and POMT2 required for enzymatic activity

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Population

mammalian cells

Comparison

coexpression of both POMT1 and POMT2 vs expression of either POMT1 or POMT2 alone

Design

Preclinical

Authors

HMHiroshi ManyaTokyo Metropolitan Institute of Gerontology ACAtsuro ChibaKyorin University AYAruto YoshidaEY Technologies (United States)

Discussion

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Implication

Both POMT1 and POMT2 required for mammalian O-mannosyltransferase activity; leaves open therapeutic targeting in human glycosylation disorders.

Structured PICO

Population

mammalian cells

Intervention

coexpression of both POMT1 and POMT2

Comparator

expression of either POMT1 or POMT2 alone

Outcome

protein O-mannosyltransferase activitysurrogate

Demonstrates that the active mammalian protein O-mannosyltransferase enzyme requires a complex of both POMT1 and POMT2, providing a method to assay this activity.

Cite This Study

Manya et al. (2003) studied this question.

synapsesocial.com/papers/69dec5fdfd84e72eb2558c6b https://doi.org/10.1073/pnas.0307228101

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Implication

Both POMT1 and POMT2 required for mammalian O-mannosyltransferase activity; leaves open therapeutic targeting in human glycosylation disorders.

Demonstration of mammalian protein O -mannosyltransferase activity: Coexpression of POMT1 and POMT2 required for enzymatic activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Demonstration of mammalian protein O -mannosyltransferase activity: Coexpression of POMT1 and POMT2 required for enzymatic activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider