What question did this study set out to answer?

To identify patient- and product-related factors influencing posttransfusion platelet count increments, intervals between transfusions, and the development of platelet refractoriness.

February 3, 2005BloodOpen Access

Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients

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Authors

SSSherrill J. SlichterUniversity of Washington

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Implication

Trial analysis demonstrates multiple clinical determinants of transfusion efficacy in thrombocytopenic patients, highlighting modifiable product factors to prevent refractoriness.

Key Points

To identify patient- and product-related factors influencing posttransfusion platelet count increments, intervals between transfusions, and the development of platelet refractoriness.
Analyzed data from 6,379 platelet transfusions administered to 533 thrombocytopenic patients enrolled in the Trial to Reduce Alloimmunization to Platelets (TRAP).
Evaluated the impact of clinical characteristics and product preparation methods on posttransfusion platelet increments, transfusion intervals, and refractoriness.
Platelet refractoriness occurred in 27% of patients and was associated with lymphocytotoxic antibodies, heparin, fever, bleeding, increasing transfusion count, greater weight, male gender, and at least two prior pregnancies.
Posttransfusion platelet increments were improved by splenectomy, older patient age, ABO-compatible platelets, storage duration of 48 hours or less, and higher platelet doses.
Overall platelet refractoriness rates were reduced exclusively by transfusing larger platelet doses or utilizing filtered apheresis platelets, whereas ultraviolet B or gamma irradiation generally diminished platelet responses.

Cite This Study

Sherrill J. Slichter (2005) studied this question.

synapsesocial.com/papers/69dec605210a0977fce958eb https://doi.org/10.1182/blood-2003-08-2724

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Implication

Trial analysis demonstrates multiple clinical determinants of transfusion efficacy in thrombocytopenic patients, highlighting modifiable product factors to prevent refractoriness.

Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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