Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type

Elizabeth A. Raupach; Apurva M. Hegde; Krystine Garcia‐Mansfield; Marice Alcantara; D. L. ROSE; Rebecca F. Halperin; Krystal A. Orlando; Jessica D. Lang; Ritin Sharma; Victoria David‐Dirgo; Salvatore Facista; Rayvon Moore; Rochelle Kofman; Zoe N. Jensen; Victoria Zismann; Anthony N. Karnezis; Yemin Wang; Lynda Bennett; Timothy G. Whitsett; Marcin Kortylewski; William P.D. Hendricks; David G. Huntsman; Lorna Rodrı́guez-Rodrı́guez; Bernard E. Weissman; Jeffrey M. Trent; Patrick Pirrotte

doi:10.1158/0008-5472.can-24-0044

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Abstract

SCCOHT, a rare ovarian cancer, features splicing dysregulation due to SMARCA4 loss that generates immunostimulatory peptides linked to potential immune responses and therapeutic avenues, challenging traditional views of the role of SMARCA4.

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Raupach et al. (2025) studied this question.

synapsesocial.com/papers/69dec93757c7c8340a5594aa https://doi.org/10.1158/0008-5472.can-24-0044

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Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type

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Abstract

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Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type

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Abstract

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