Proteomic analysis supports the comorbidity-inflammation paradigm in HFpEF, linking comorbidity burden to worse hemodynamics and right ventricular dysfunction via inflammatory protein networks.
Supports inflammation-comorbidity paradigm in HFpEF; hypothesis-generating and should not change practice without prospective trials.
Proteins involved in inflammation form a conserved network in HFpEF across 2 independent cohorts and may mediate the association between comorbidity burden and echocardiographic indicators of worse hemodynamics and right ventricular dysfunction. These findings support the comorbidity-inflammation paradigm in HFpEF.
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Wijk et al. (2020) studied this question.
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