Lipidomic analysis reveals altered serum phospholipid profiles in early-stage osteoarthritis patients, suggesting a systemic metabolic response before joint damage appears on radiographs.
The significant lipidomic alterations that were detected at an average Outerbridge score of less than 2 suggest that certain serum PLs may serve as indicators for monitoring the early stages of OA even before radiologic detection is possible. With 10% of PL species elevated only in OA serum, our data implicate the existence of a systemic response that parallels the local lipid metabolic response to OA.
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Eichner et al. (2025) studied this question.
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