HIV protease inhibitors activate the adipose renin-angiotensin system in vitro, suggesting a mechanism for PI-induced hypertension and a potential therapeutic role for ARBs.
May link PIs to hypertension via adipose RAS; leaves open ARB utility in patients.
We report that two frequently prescribed PI combinations could activate the adipose RAS in cultured cells, in part through a PPAR-gamma-dependant signalling pathway. Our data suggest a role for the adipose RAS in the development of hypertension in HIV-infected patients under PI treatment, and point out the potential use of ARBs to decrease PI adverse effects.
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Boccara et al. (2009) studied this question.
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