What does this research mean for the field?

Obesity-related hypertension is associated with increased activity of both the adipose and systemic renin-angiotensin system, driven by elevated angiotensinogen expression in adipose tissue. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to investigate changes in the renin-angiotensin system (RAS) in adipose tissue and circulation in diet-induced obese hypertensive rats.

June 15, 2004AJP Regulatory Integrative and Comparative Physiology

Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

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Why the study?

Does a moderately high-fat diet induce activation of the adipose and systemic renin-angiotensin system in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Comparison

Moderately high-fat diet for 11 weeks vs Low-fat diet (11% kcal as fat) for 11 weeks

Design

Preclinical

Follow-up

11 weeks

Authors

CBCarine BoustanyBoehringer Ingelheim (United States)KBKalyani G. BharadwajUniversity of Kentucky ADAlan DaughertyGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May link high-fat diet to adipose RAS activation in obese rats; leaves open human translation and therapeutic targeting.

Key Points

This study aims to investigate changes in the renin-angiotensin system (RAS) in adipose tissue and circulation in diet-induced obese hypertensive rats.
Male Sprague-Dawley rats were fed low-fat (11% kcal) or high-fat (32% kcal) diets for 11 weeks.
After 8 weeks, weight gain categorized rats into obesity-prone and obesity-resistant groups.
mRNA expression of angiotensinogen was quantified using real-time PCR, and plasma concentrations were measured.
Obesity-prone rats had a significant increase in mean arterial blood pressure (OP: 105 +/- 1 mmHg, P < 0.05).
Angiotensinogen gene expression was doubled in retroperitoneal adipose tissue of OP rats compared to OR and LF groups (P < 0.05).
Plasma angiotensin II concentration was significantly elevated in OP rats (OP: 295 +/- 118 pg/ml, P < 0.05).

Structured PICO

Does a moderately high-fat diet induce activation of the adipose and systemic renin-angiotensin system in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Intervention

Moderately high-fat diet (32% kcal as fat) for 11 weeks

Comparator

Low-fat diet (11% kcal as fat) for 11 weeks

Outcome

Changes in components of the adipose and systemic renin-angiotensin system (RAS)surrogate

Diet-induced obesity in rats is associated with increased activity of both the adipose and systemic renin-angiotensin systems, contributing to obesity-related hypertension.

Cite This Study

Boustany et al. (2004) studied this question.

synapsesocial.com/papers/6a1bcf23ea84844e355f00e4 https://doi.org/10.1152/ajpregu.00265.2004

Topics

Hypertension management

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Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider