Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study

This is the authors' abstract. We don't add key points for this paper.

This is the first large-scale study to report an association between antidepressant response history and subsequent change in diagnosis from major depressive disorder to bipolar disorder. Our findings support the view that a history of poor response to antidepressants in unipolar depression could be a useful predictor for bipolar diathesis.