February 19, 2001Acta Physiologica Scandinavica

Role of adenosine in exercise‐induced human skeletal muscle vasodilatation

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Why the study?

Does adenosine mediate exercise-induced skeletal muscle vasodilatation in humans?

Structured PICO

Does adenosine mediate exercise-induced skeletal muscle vasodilatation in humans?

Population

13 human subjects (6 evaluated for theophylline-induced adenosine receptor blockade, 7 for adenosine infusion)

Intervention

Intravenous theophylline during one-legged knee-extensor exercise; and adenosine infusion (bolus 2.5 mg and continuous) in the femoral artery at rest and during exercise

Comparator

Baseline/rest conditions and exercise without intervention

Outcome

Femoral artery blood flow (FaBF) and leg vascular conductance (VC)surrogate

Endogenous adenosine controls approximately 20% of the hyperaemic response to submaximal exercise in human skeletal muscle.

Discussion

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Implication

Adenosine partially mediates exercise hyperemia; leaves open its dominance versus other vasodilators in health and disease.

Cite This Study

Rådegran et al. (2001) studied this question.

synapsesocial.com/papers/69dee41644e8c00149b0bd40 https://doi.org/10.1046/j.1365-201x.2001.00796.x

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Role of adenosine in exercise‐induced human skeletal muscle vasodilatation

Structured PICO

Discussion

Implication

Cite This Study

Role of adenosine in exercise‐induced human skeletal muscle vasodilatation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider