May 12, 2026European Heart Journal
Vascular control by purines with emphasis on the coronary system
Key result
Purines regulate coronary blood flow and vascular tone via multi-cellular purinoceptor signaling.
Population
Vascular and coronary systems (basic science review)
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Purines such as ATP and adenosine have complex, multifaceted roles in regulating vascular tone, particularly in the coronary system, through various receptor-mediated mechanisms.
Structured PICO
P
Population
Vascular and coronary systems (basic science review)
I
Intervention
Purines (ATP, adenosine)
O
Outcome
Vascular control (vasoconstriction and vasodilatation)
Purines such as ATP and adenosine have complex, multifaceted roles in regulating vascular tone, particularly in the coronary system, through various receptor-mediated mechanisms.
Cite This Study
Geoffrey Burnstock (1989) conducted a review in Vascular control and coronary blood flow. Purines (ATP and adenosine) was evaluated. Purines, including ATP and adenosine, play multiple roles in vascular control and coronary blood flow regulation via purinoceptors on nerves, smooth muscle, and endothelial cells.