Stereotactic magnetic resonance-guided online adaptive radiotherapy of adrenal metastases combines high ablative doses with optimized sparing of organs at risk

Philipp Hoegen; Efthimios Katsigiannopulos; Carolin Buchele; Sebastian Regnery; Fabian Weykamp; Elisabetta Sandrini; Jonas Ristau; Jakob Liermann; Eva Meixner; Tobias Förster; C. Katharina Renkamp; Fabian Schlüter; Carolin Rippke; Jürgen Debus; Sebastian Klüter; Juliane Hörner‐Rieber

doi:10.1016/j.ctro.2022.100567

December 19, 2022SHILAP Revista de lepidopterologíaOpen Access

Stereotactic magnetic resonance-guided online adaptive radiotherapy of adrenal metastases combines high ablative doses with optimized sparing of organs at risk

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Key Points

To assess whether stereotactic magnetic resonance-guided online adaptive radiotherapy achieves target dose requirements for adrenal metastases while adequately protecting surrounding critical structures.
Assessed stereotactic magnetic resonance-guided online adaptive radiotherapy (SMART) for the treatment of adrenal metastases in a clinically challenging patient cohort.
Evaluated target dose coverage for gross tumor volume (GTV) and planning target volume (PTV) against standard dose constraints for organs at risk.
SMART achieved established ablative dose recommendations across gross tumor volume and planning target volume targets.
Critical organs at risk were successfully spared from excessive radiation exposure despite anatomically complex tumor locations.

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Implication

Clinical evaluation demonstrates stereotactic MRI-guided adaptive radiotherapy delivers ablative doses while sparing organs at risk in adrenal metastases, indicating improved therapeutic safety.

Abstract

SMART fulfills established GTV and PTV dose recommendations while simultaneously sparing organs at risk even in a challenging cohort.

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Hoegen et al. (2022) studied this question.

synapsesocial.com/papers/69deff87b2fdddf6a7edbc80 https://doi.org/10.1016/j.ctro.2022.100567

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Stereotactic magnetic resonance-guided online adaptive radiotherapy of adrenal metastases combines high ablative doses with optimized sparing of organs at risk

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Stereotactic magnetic resonance-guided online adaptive radiotherapy of adrenal metastases combines high ablative doses with optimized sparing of organs at risk

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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