November 24, 2003Antimicrobial Agents and ChemotherapyOpen Access

Phase II, Randomized, Double-Blind, Placebo-Controlled Studies of Ruprintrivir Nasal Spray 2-Percent Suspension for Prevention and Treatment of Experimentally Induced Rhinovirus Colds in Healthy Volunteers

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Why the study?

Does intranasal ruprintrivir prevent or treat experimentally induced rhinovirus colds in healthy volunteers?

Population

202 healthy volunteers with experimentally induced rhinovirus colds

Comparison

Intranasal ruprintrivir spray as prophylaxis or… vs Placebo sprays

Design

RCT, Randomized, Double-blind, placebo-controlled

Follow-up

4 to 5 days

Authors

FHFrederick G. HaydenResearch Council of Finland RTRonald B. TurnerRoyal Geographical Society JGJack M. GwaltneyRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Supports evaluation in natural infections; confirms activity in human challenge model and warrants further development.

Structured PICO

Does intranasal ruprintrivir prevent or treat experimentally induced rhinovirus colds in healthy volunteers?

Population

202 healthy volunteers with experimentally induced rhinovirus colds

Intervention

Intranasal ruprintrivir (8 mg) spray as prophylaxis (2x/day or 5x/day for 5 days starting 6 h before infection) or as treatment (5x/day for 4 days starting 24 h after infection)

Comparator

Placebo sprays

Outcome

Proportion of subjects with positive viral cultures (prophylaxis) and mean total daily symptom score (treatment)patient reported

Intranasal ruprintrivir reduces viral shedding when used as prophylaxis and improves symptom scores when used as treatment for experimental rhinovirus infection.

Cite This Study

Hayden et al. (2003) studied this question.

synapsesocial.com/papers/69df108b3b0ba53fb37a1125 https://doi.org/10.1128/aac.47.12.3907-3916.2003

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Phase II, Randomized, Double-Blind, Placebo-Controlled Studies of Ruprintrivir Nasal Spray 2-Percent Suspension for Prevention and Treatment of Experimentally Induced Rhinovirus Colds in Healthy Volunteers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phase II, Randomized, Double-Blind, Placebo-Controlled Studies of Ruprintrivir Nasal Spray 2-Percent Suspension for Prevention and Treatment of Experimentally Induced Rhinovirus Colds in Healthy Volunteers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider