Why the study?
Does perineural dexamethasone prolong analgesia duration in patients undergoing brachial plexus blockade?
Does perineural dexamethasone prolong analgesia duration in patients undergoing brachial plexus blockade?
A 4 mg dose of perineural dexamethasone appears to be the ceiling dose for prolonging analgesia after brachial plexus blockade, though the current evidence quality is very low.
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May guide 4 mg dosing in brachial plexus blocks; very low-quality evidence leaves confirmation to future trials.
There is currently very low quality evidence that 4 mg of perineural dexamethasone represents a ceiling dose that prolongs analgesia duration by a mean period of 6 and 8 hours when combined with short-/intermediate- or long-acting local anesthetics, respectively. Additional data are needed to explore the threshold for this effect, particularly with doses below 4 mg. The risk of neurologic complications is probably not increased (very low evidence).
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Kirkham et al. (2017) studied this question.
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