CaMKII phosphorylation of RyR2 at S2814 contributes to sarcoplasmic reticulum calcium leak and heart failure progression in nonischemic murine models.
Our results suggest that increased CaMKII phosphorylation of RyR2 plays a role in the development of pathological sarcoplasmic reticulum Ca(2+) leak and HF development in nonischemic forms of HF such as transverse aortic constriction in mice.
Respress et al. (Wed,) studied this question.