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April 1, 1975Journal of Biological ChemistryOpen Access

Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.

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Population

Cardiac microsomes

Design

Preclinical

Authors

MTMichihiko TadaMKM A KirchbergerAKAM Katz

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Overview

Establishes cAMP-dependent modulation of cardiac SR calcium handling in animals; leaves open translation to human therapies.

Structured PICO

P
Population
Cardiac microsomes
I
Intervention
Incubation with [gamma-32P]ATP and a cardiac adenosine 3':5'-monophosphate (cyclic AMP)-dependent protein kinase
O
Outcome
Phosphorylation of a 22,000-dalton microsomal protein componentsurrogate

Demonstrates that a 22,000-dalton protein in the cardiac sarcoplasmic reticulum is phosphorylated by cAMP-dependent protein kinase, acting as a modulator of the calcium pump.

Cite This Study

Tada et al. (1975) studied this question.

synapsesocial.com/papers/69df18eed85e58e37b7a136fhttps://doi.org/10.1016/s0021-9258(19)41650-5
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