Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1974Journal of Biological ChemistryOpen Access

Adenosine 3′:5′-Monophosphate-dependent Protein Kinase-catalyzed Phosphorylation Reaction and Its Relationship to Calcium Transport in Cardiac Sarcoplasmic Reticulum

View Full Paper
Ask AI
Bookmark
Share

Population

Cardiac microsomes consisting primarily of sarcoplasmic reticulum

Comparison

Incubation with cyclic AMP-dependent protein… vs Incubation without added protein kinase or…

Design

Preclinical

Authors

MKMadeleine A. KirchbergerIcahn School of Medicine at Mount SinaiMTMichihiko TadaUniversity of VermontAKArnold M. KatzHeart Failure / Cardiomyopathy

Discussion

Loading...

Member takes

Implication

Supports cAMP-dependent phosphorylation in cardiac calcium transport; leaves open translation to human disease or therapy.

Structured PICO

P
Population
Cardiac microsomes consisting primarily of sarcoplasmic reticulum
I
Intervention
Incubation with cyclic AMP-dependent protein kinase and cyclic AMP, or epinephrine
C
Comparator
Incubation without added protein kinase or cyclic AMP
O
Outcome
Phosphorylation of cardiac microsomes and rate of calcium uptakesurrogate

The study demonstrates a functional relationship between cardiac microsomal phosphorylation by cyclic AMP-dependent protein kinase and an increased rate of calcium transport.

Cite This Study

Kirchberger et al. (1974) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47c1https://doi.org/10.1016/s0021-9258(19)42236-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rate of Calcium Binding and Uptake in Normal Animal and Failing Human Cardiac Muscle: MEMBRANE VESICLES (RELAXING SYSTEM) AND MITOCHONDRIA1969 · 520 citations
  2. 2Sodium and Potassium Sensitivity of Calcium Uptake and Calcium Binding by Dog Cardiac Microsomes1967 · 49 citations
  3. 3Some Properties of Fragmented Frog Sarcoplasmic Reticulum with Particular Reference to Its Response to Caffeine*1970 · 145 citations
  4. 4The Stimulation of Calcium Transport in Cardiac Sarcoplasmic Reticulum by Adenosine 3′:5′-Monophosphate-dependent Protein Kinase1974 · 408 citations
  5. 5Molecular Forms and Subunit Composition of a Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase Purified from Bovine Heart Muscle1972 · 255 citations