November 11, 1980Biochemistry

Mechanism of the stimulation of calcium ion dependent ATPase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase

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Why the study?

Does cAMP-dependent phosphorylation of canine cardiac sarcoplasmic reticulum stimulate the calcium pump?

Population

Canine cardiac sarcoplasmic reticulum (SR)

Comparison

Preincubation with cAMP and cAMP-dependent… vs Preincubation with cAMP and cAMP-dependent…

Design

Preclinical

Authors

EKEvangelia G. KraniasHeart Failure & Transplant FMFrederic MandelUniversity of Maryland, Baltimore ASArnold SchwartzElectrophysiology

Discussion

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Implication

May support PKA modulation of SR Ca2+ pump in canine models; leaves open human therapeutic relevance.

Structured PICO

Does cAMP-dependent phosphorylation of canine cardiac sarcoplasmic reticulum stimulate the calcium pump?

Population

Canine cardiac sarcoplasmic reticulum (SR)

Intervention

Preincubation with cAMP and cAMP-dependent protein kinase in the presence of ATP (phosphorylated SR)

Comparator

Preincubation with cAMP and cAMP-dependent protein kinase in the absence of ATP (control)

Outcome

Formation (4-200 ms) and decomposition (0-73 ms) of the acid-stable phosphorylated enzyme (E~P) of Ca2+-ATPasesurrogate

Phosphorylation of cardiac sarcoplasmic reticulum by cAMP-dependent protein kinase regulates several steps in the Ca2+-ATPase reaction sequence, leading to overall stimulation of the calcium pump.

Cite This Study

Kranias et al. (1980) studied this question.

synapsesocial.com/papers/6a7d27778253d2b4939ffe4c https://doi.org/10.1021/bi00564a044

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Mechanism of the stimulation of calcium ion dependent ATPase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of the stimulation of calcium ion dependent ATPase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider