What does this research mean for the field?

A cAMP-stimulated protein kinase and its specific protein substrate are present in the cardiac sarcoplasmic reticulum and exhibit distinct biochemical properties, suggesting they mediate cAMP-stimulated calcium uptake in the heart. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1973Journal of Biological ChemistryOpen Access

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

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Structured PICO

Population

Morphologically and enzymatically defined sarcoplasmic reticulum preparation from canine heart

Intervention

Cyclic adenosine 3',5'-monophosphate (cAMP)

Comparator

Absence of cAMP

Outcome

Self-phosphorylation of sarcoplasmic reticulum vesicles and kinase activitysurrogate

Identified a cAMP-stimulated protein kinase and substrate in canine cardiac sarcoplasmic reticulum, providing a potential biochemical mechanism for cAMP-stimulated calcium uptake.

Discussion

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Implication

Offers biochemical basis for cAMP effects on cardiac SR calcium uptake; extends prior animal observations but leaves open human relevance.

Cite This Study

Wray et al. (1973) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47c3 https://doi.org/10.1016/s0021-9258(19)44327-5

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Implication

Offers biochemical basis for cAMP effects on cardiac SR calcium uptake; extends prior animal observations but leaves open human relevance.

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

Structured PICO

Discussion

Implication

Cite This Study

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider