Trans-synaptic degeneration as a mechanism of neurodegeneration in multiple sclerosis

Olwen C. Murphy; Peter A. Calabresi; Shiv Saidha

doi:10.4103/1673-5374.373661

April 10, 2023Neural Regeneration ResearchOpen Access

Trans-synaptic degeneration as a mechanism of neurodegeneration in multiple sclerosis

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine whether acute optic neuritis triggers anterograde and retrograde trans-synaptic neurodegeneration across the visual pathway in patients with multiple sclerosis or high-risk clinically isolated syndrome.
Tracked 49 participants recruited within 40 days of acute optic neuritis (AON) onset alongside 73 non-AON comparator participants with multiple sclerosis for up to 5 years.
Conducted serial optical coherence tomography to quantify retinal layer thicknesses and annual brain MRI to measure regional brain volume changes.
Participants with AON exhibited accelerated annual volume loss compared to controls in the thalamus (-1.17% vs. -0.67%, P = 0.02), occipital gray matter (-0.76% vs. -0.22%, P = 0.01), and calcarine gray matter (-1.83% vs. -0.32%, P = 0.008).
Eyes affected by AON experienced greater 1-year reductions in inner nuclear layer thickness than non-AON eyes (-3.73% vs. -2.34%, P = 0.02), suggesting retrograde trans-synaptic degeneration.
Greater first-year thinning of the ganglion cell-inner plexiform layer correlated with faster subsequent thalamic atrophy, which linked directly to poorer long-term visual recovery.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Observational cohort study demonstrates accelerated posterior visual pathway atrophy after optic neuritis in multiple sclerosis, highlighting trans-synaptic degeneration as a clinical driver.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Murphy et al. (2023) studied this question.

synapsesocial.com/papers/69df1926b8d7e94566614736 https://doi.org/10.4103/1673-5374.373661

View Full Paper

Ask AI

Bookmark

Share

Trans-synaptic degeneration as a mechanism of neurodegeneration in multiple sclerosis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Trans-synaptic degeneration as a mechanism of neurodegeneration in multiple sclerosis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

More related papers

More from Neural Regeneration Research

Keep reading

More related papers

More from Neural Regeneration Research