Does a high dose of norepinephrine increase the haemodynamic effect of volume expansion on mean systemic pressure in septic shock compared to a low dose?
Higher doses of norepinephrine potentiate the haemodynamic response to volume expansion in patients with septic shock.
Norepinephrine enhances the Pms increase induced by PLR. These results suggest that a bolus of fluid of the same volume has a greater haemodynamic effect at a high dose than at a low dose of norepinephrine during septic shock.
Adda et al. (Sat,) studied this question.