Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock

Fig. 1. Study design. BaselineLow: baseline at the low dose of norepinephrine, BaselineHigh: baseline at the high dose of norepinephrine, NE: norepinephrine, PLRLow: passive leg raising at the low dose of norepinephrine; PLRHigh: passive leg raising at the high dose of norepinephrine, Pms: mean systemic pressure, ∆Pms: changes in mean systemic pressure induced by passive leg raising

Fig. 2. Changes in mean systemic pressure during the study protocol. BaselineLow: baseline at the low dose of norepinephrine, BaselineHigh: baseline at the high dose of norepinephrine, PLRLow: passive leg raising at the low dose of norepinephrine; PLRHigh: passive leg raising at the high dose of norepinephrine, Pms: mean systemic pressure. *p < 0.05 vs. BaselineHigh, **p < 0.05 vs. BaselineLow. N = 30, mean [standard deviation]

Fig. 3. Changes in mean systemic pressure (∆Pms) induced by passive leg raising (PLR) at the highest and the lowest dose of norepinephrine (NE). N = 30, individual values and mean [standard deviation]