June 25, 2004Journal of Clinical Pathology355 citationsOpen Access

The effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study

VAVasilios G. AthyrosPreventive Cardiology DMD. P. MikhailidisUniversity College London APAthanasios A. PapageorgiouDelft University of Technology

Structured PICO

Does statin treatment prevent the decline of renal function in dyslipidaemic patients with coronary heart disease?

Population

Dyslipidaemic patients with coronary heart disease (CHD) and normal renal function at baseline

Intervention

Statin treatment (atorvastatin)

Comparator

Untreated dyslipidaemia

Outcome

Change in creatinine clearance (CrCl)surrogate

Statin therapy prevents the decline of and improves renal function (CrCl) over three years in dyslipidemic patients with CHD.

Abstract

In untreated dyslipidaemic patients with CHD and normal renal function at baseline, CrCl declines over a period of three years. Statin treatment prevents this decline and significantly improves renal function, potentially offsetting an additional factor associated with CHD risk.

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