Why the study?
Do hypertension and dyslipidemia accelerate the decline in renal function in dyslipidemic middle-aged men without renal disease?
Population
2,702 dyslipidemic middle-aged men without renal disease participating in the Helsinki Heart Study
Comparison
Elevated ratio of low- to high-density… vs Ratio of low- to high-density lipoprotein…
Design
Cohort
Follow-up
5 years
Authors
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May support combined BP-lipid monitoring to slow renal decline; hypothesis-generating and leaves causal effects open for randomized confirmation.
Do hypertension and dyslipidemia accelerate the decline in renal function in dyslipidemic middle-aged men without renal disease?
Simultaneous elevation of blood pressure and atherogenic lipids synergistically accelerates the decline of renal function in middle-aged men without baseline renal disease.
Mänttäri et al. (1995) studied this question.
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