Epigenetic analysis reveals fetal hypoxia programs a cardiac pro-inflammatory phenotype during development, suggesting antenatal stress increases adult heart disease susceptibility.
Our study provides an initial framework and new insights into foetal hypoxia-mediated epigenetic programming of pro-inflammatory phenotype in the heart development, linking antenatal stress, and developmental programming of heart vulnerability to disease later in life.
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Huang et al. (2018) studied this question.
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