Population
Isolated, pressurized gracilis muscle arterioles from control and methionine diet–induced…
Comparison
Increases in intraluminal flow and… vs Control arterioles from non-HHcy rats
Design
Preclinical
Authors
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May indicate microvascular dysfunction mechanism in hyperhomocysteinemia; leaves open clinical relevance of xanthine oxidase targeting.
In hyperhomocysteinemia, xanthine oxidase-derived superoxide scavenges NO to form peroxynitrite, promoting thromboxane A2 release and converting flow-induced arteriolar dilation to constriction.
Bagi et al. (2002) studied this question.
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