What question did this study set out to answer?

To assess the global prevalence of isoniazid-resistant tuberculosis and characterize resistance patterns to other key antituberculosis drugs.

January 21, 2020PLoS MedicineOpen Access

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data

View Full Paper

Ask AI

Bookmark

To assess the global prevalence of isoniazid-resistant tuberculosis and characterize resistance patterns to other key antituberculosis drugs.
Conducted a multicountry cross-sectional analysis evaluating patients with tuberculosis for isoniazid-resistant disease (Hr-TB).
Assessed diagnostic gaps under standard rifampicin-guided testing algorithms and analyzed co-resistance to pyrazinamide and fluoroquinolones.
Global prevalence of isoniazid-resistant tuberculosis was higher than the prevalence of rifampicin resistance.
Diagnostic algorithms dependent primarily on rifampicin testing failed to detect a substantial proportion of isoniazid-resistant tuberculosis cases.
Resistance to pyrazinamide and fluoroquinolones remained low among individuals with isoniazid-resistant tuberculosis, supporting current modified treatment guidelines.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Cross-sectional analysis reveals high isoniazid resistance rates exceeding rifampicin resistance in tuberculosis patients, highlighting the need for improved molecular diagnostics.

Cite This Study

Dean et al. (2020) studied this question.

synapsesocial.com/papers/69df23bbd5404a0bea592254 https://doi.org/10.1371/journal.pmed.1003008

View Full Paper

Ask AI

Bookmark

Implication

Cross-sectional analysis reveals high isoniazid resistance rates exceeding rifampicin resistance in tuberculosis patients, highlighting the need for improved molecular diagnostics.

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data

Key Points

Discussion

Implication

Cite This Study

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider