Key result
Hedgehog signaling reactivates in adult muscle to regulate angiogenesis during regeneration following ischemia.
Why the study?
The role of Hedgehog signaling in adult skeletal muscle ischemia and its regulatory effect on angiogenesis during muscle regeneration was not established.
Key points are not available for this paper at this time.
Design
Experimental study on adult skeletal muscle ischemia
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May identify Hedgehog reactivation as a target for ischemic muscle repair; leaves open clinical translation to peripheral artery disease.
Pola et al. (2003) studied this question. Hedgehog signaling is reactivated postnatally in adult muscular tissues and regulates angiogenesis during muscle regeneration following skeletal muscle ischemia.
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