Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions

Lamia Boubakri; Sabri Hassen; Nevin Gürbüz; İsmail Özdemir; Youssef Arfaoui; Anis Attour; Harald Kelm; Jamil Kraı̈em; Naceur Hamdi

doi:10.1039/d6ra00146g

January 1, 2026RSC AdvancesOpen Access

Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions

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Key Points

To explore the synthesis and catalytic properties of novel Pd-PEPPSI-NHC complexes for N-alkylation reactions.
Synthesized Pd-PEPPSI-NHC complexes
Characterized structures using X-ray diffraction
Evaluated catalytic performance in N-alkylation of amines and alcohols
Successfully performed N-alkylation using Pd-PEPPSI-NHC complexes
Demonstrated effectiveness in the borrowing-hydrogen approach
First report of this catalyst class in N-alkylation transformations

Implication

Novel Pd-PEPPSI-NHC complexes enable N-alkylation of amines, suggesting new catalytic applications.

Abstract

Herein, we describe the borrowing-hydrogen N -alkylation of amines with alcohols using Pd-PEPPSI-NHC complexes, representing the first example of this catalyst class applied to this transformation.

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Cite This Study

Boubakri et al. (2026) studied this question.

synapsesocial.com/papers/69df2a99e4eeef8a2a6afac5 https://doi.org/10.1039/d6ra00146g

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Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel NHC-based Pd–PEPPSI complexes: synthesis, structural characterization by X-ray diffraction, biological properties, and catalytic performance in N -alkylation reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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