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April 15, 2026Journal of PerinatologyOpen Access

Effects of a respiratory care protocol incorporating less invasive surfactant administration in infants born at 30–34 weeks’ gestation

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Authors

SASwathi AriyapadiLBLorraine BautistaLDLebanon David

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Overview

Comparative analysis reveals reduced mechanical ventilation needs in preterm infants following a new care protocol, suggesting improved outcomes.

Key Points

  • Evaluate the effectiveness of a respiratory care protocol incorporating less invasive surfactant administration in preterm infants.
  • Analyzed two cohorts of preterm infants: pre-RCP (Jan 2017 - Sept 2018) and post-RCP (Oct 2018 - Dec 2020).
  • Included infants receiving CPAP for at least 24 hours and excluded those intubated at birth.
  • Compared maternal and neonatal outcomes, including CPAP levels and mechanical ventilation needs.
  • Post-RCP infants had higher antenatal steroid exposure and lower median gestational age.
  • Post-RCP cohort required lower mechanical ventilation within the first 72 hours of life and during hospital stay.
  • Increased CPAP administration was noted in the delivery room and at admission in the post-RCP group.

Cite This Study

Ariyapadi et al. (2026) studied this question.

synapsesocial.com/papers/69df2abce4eeef8a2a6afc3chttps://doi.org/10.1038/s41372-026-02682-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CPAP Versus NIPPV Postextubation in Preterm Neonates: A Comparative-Effectiveness Study2024 · 7 citations
  2. 2Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants2021 · 19 citations
  3. 3Summary Proceedings From the Bronchopulmonary Dysplasia Group2006 · 259 citations
  4. 4Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome2021 · 178 citations
  5. 5A Survey of Minimally Invasive Surfactant Use in the United States2024 · 5 citations