Why the study?
Does AIF-1 expression correlate with cardiac rejection and development of cardiac allograft vasculopathy in cardiac allografts?
Does AIF-1 expression correlate with cardiac rejection and development of cardiac allograft vasculopathy in cardiac allografts?
AIF-1 expression may serve as a biomarker for cardiac allograft rejection severity and the development of cardiac allograft vasculopathy.
May support AIF-1 monitoring for rejection and CAV risk; hypothesis-generating and should not yet change practice.
Expression of AIF-1 in cardiac allografts correlates with rejection, and the amount of AIF-1 expressed correlates with the severity of rejection. AIF-1 is expressed in coronary arteries with CAV, and persistent expression of AIF-1 in the cardiac allograft is associated with development of CAV.
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Autieri et al. (2002) studied this question.
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