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April 15, 2026Pain

Establishing clinical significance thresholds for common pediatric pain-related patient-reported outcome measures

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Authors

BCBenedikt B. ClausASAmelie Florentine SchmidtDMDorothee Meyer

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Overview

Estimates minimally important differences in pain outcomes for pediatric patients, highlighting their clinical significance.

Key Points

  • The aim is to establish clinically significant thresholds for common pediatric PROMs in the context of pain management.
  • Analyzed data from a longitudinal multicenter study with 453 participants aged 8 to 17 years in Germany.
  • Applied equipercentile linking to connect PROM changes with global ratings of change.
  • Estimated minimally important differences for various pain-related PROMs.
  • The MID for improvement in the Functional Disability Inventory is 4.96 points.
  • The MID for anxiety in the Revised Children's Anxiety and Depression Scale is 3.32 points, while for depression it is 1.38 points.
  • A reduction of 0.64 points on the pain intensity scale indicates meaningful improvement.
  • An increase of 3.72 points in pain self-efficacy represents an MID.

Cite This Study

Claus et al. (2026) studied this question.

synapsesocial.com/papers/69df2ae6e4eeef8a2a6afe95https://doi.org/10.1097/j.pain.0000000000003972
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