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April 15, 2026Journal of Hepatocellular CarcinomaOpen Access

C/EBP-β Mediates the Reversal of Sorafenib Resistance by Tunicamycin in Hepatocellular Carcinoma

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Authors

CPChong PangJCJ. Bradley ChenMCMingyi Chu

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Overview

Demonstrates tunicamycin's ability to enhance sensitivity to sorafenib in hepatocellular carcinoma, suggesting a novel therapeutic strategy to overcome drug resistance.

Key Points

  • To investigate the role of tunicamycin in reversing sorafenib resistance in hepatocellular carcinoma through C/EBP-β modulation.
  • Established sorafenib-resistant HepG2 and Huh7 cell lines
  • Evaluated the effects of tunicamycin on cell proliferation, colony formation, ROS production, and apoptosis
  • Validated therapeutic efficacy in vivo using xenograft models
  • Tunicamycin significantly inhibited proliferation and clonogenicity of sorafenib-resistant cells
  • TM treatment upregulated C/EBP-β expression and restored sensitivity to sorafenib
  • C/EBP-β overexpression mimicked TM's effect, while its knockdown reduced TM-induced sensitization
  • In vivo, TM combined with C/EBP-β overexpression reduced tumor volume by about 91% compared to sorafenib alone

Cite This Study

Pang et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b0115https://doi.org/10.2147/jhc.s587037
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