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April 15, 2026British Journal of Dermatology0 citations

More than a symptom: itch as an independent clinical contributor in atopic dermatitis - a global-scale study on 15,223 patients

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JSJonathan I SilverbergGeorge Washington UniversityRDRoni Dodiuk-GadUniversity of TorontoRTRoberto TakaokaUniversidade de São Paulo

Key Points

  • This research aims to assess the impact of pruritus on the quality of life for patients with atopic dermatitis.
  • Conducted an international study involving 15,223 atopic dermatitis patients across 27 countries
  • Utilized validated assessment tools such as ABS-A, SOL, and PUSH-D to measure pruritus and its effects
  • Analyzed the correlation between pruritus severity and quality of life outcomes
  • Severe pruritus is found to significantly impair daily activities and professional careers of patients
  • Quality of life is notably affected due to pruritus, highlighting its role as an independent contributor to disease burden
  • There is an urgent need for systematic evaluation and targeted management strategies for pruritus in clinical practice

Abstract

This international study of 15,223 atopic dermatitis patients across 27 countries reveals that severe pruritus significantly impairs quality of life, affecting daily activities, professional careers, and social relationships. Using validated tools like ABS-A, SOL, and PUSH-D, it underscores pruritus as a key independent factor in disease burden, highlighting the urgent need for its systematic evaluation and targeted management in clinical practice.

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Cite This Study

Silverberg et al. (2026) studied this question.

synapsesocial.com/papers/69df2b49e4eeef8a2a6b03e8https://doi.org/10.1093/bjd/ljag142
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Itch, Scratching, and Sleep Mediate the Association between Disease Severity and Quality of Life in Pruritic Dermatoses: A Cross-Sectional Study2026
  2. 2Beyond the Skin: Assessing Itch in Atopic Dermatitis – Insights from UK Dermatologists. A Cross-Sectional Survey and Narrative Review2026
  3. 3Predicting Factors and Clinical Characteristics of Pruritus in Psoriasis: A Cross-Sectional Survey2024 · 2 citations
  4. 4International study on prevalence of itch: examining the role of itch as a major global public health problem2024 · 32 citations
  5. 5688 - The heterogeneous characteristics of itch vary by atopic dermatitis severity and differentially impact quality of life in children and adults: a prospective cohort study2024 · 1 citations