Multi-center analysis highlights antibody prevalence and antigen patterns in sickle cell disease, suggesting improved testing strategies.
Substantial institutional variation in antibody prevalence suggests need for site-specific approaches to testing and prophylactic matching. High co-occurrence of auto- and alloantibodies, antibody immunogenicity patterns, and antigen-antibody discordances support the need for further research and consideration of refined testing and/or matching strategies beyond the current Rh and K standard.
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Covington et al. (2026) studied this question.
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