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April 15, 2026European Heart Journal - Cardiovascular PharmacotherapyOpen Access

SGLT2 inhibitors serve as foundational disease-modifying therapies for CKM syndrome requiring proactive multidisciplinary coordination.

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Why the study?

Shifting from reactive to proactive CKM management requires an integrated care model aligning specialties around early, organ-protective interventions.

Design

Multidisciplinary expert perspective

Key result

SGLT2 inhibitors serve as foundational, disease-modifying therapies for Cardiovascular-Kidney-Metabolic syndrome requiring proactive, multidisciplinary coordination for optimal management.

Authors

AAAngelo AvogaroMGMauro GoriGGGiuseppe Grandaliano

Discussion

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Overview

Requires proactive multidisciplinary coordination for CKM syndrome; extends SGLT2 inhibitors as foundational disease-modifying therapy.

Key Points

  • The research aims to outline the importance of integrating SGLT2 inhibitors in managing cardiovascular-kidney-metabolic syndrome.
  • Identified the need for a proactive management approach to CKM syndrome.
  • Proposed a multidisciplinary coordination model among various medical specialties.
  • Emphasized the establishment of clinical algorithms for early interventions.
  • SGLT2 inhibitors should be viewed as foundational, disease-modifying therapies.
  • Improved patient outcomes are expected through better integration of care.
  • Clear communication strategies can enhance understanding and adherence to interventions.

Structured PICO

P
Population
Patients with Cardiovascular-Kidney-Metabolic (CKM) Syndrome
I
Intervention
SGLT2 inhibitors implemented via an integrated multidisciplinary care model

Expert perspective emphasizes proactive, multidisciplinary management of CKM syndrome with SGLT2 inhibitors as foundational therapy.

Cite This Study

Avogaro et al. (2026) studied this question. SGLT2 inhibitors serve as foundational, disease-modifying therapies for Cardiovascular-Kidney-Metabolic syndrome requiring proactive, multidisciplinary coordination for optimal management.

synapsesocial.com/papers/69df2ba0e4eeef8a2a6b0a55https://doi.org/10.1093/ehjcvp/pvag020
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