Why the study?
Does the PNPLA3 rs738409 polymorphism affect the risk of developing non-alcoholic fatty liver disease?
Comparison
PNPLA3 rs738409 genotypes (CC vs CG vs GG vs CG + GG)
Design
Systematic review and meta-analysis
Authors
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PNPLA3 rs738409 testing may refine NAFLD risk stratification; confirms G allele as a major susceptibility factor.
Does the PNPLA3 rs738409 polymorphism affect the risk of developing non-alcoholic fatty liver disease?
The PNPLA3 rs738409 polymorphism is significantly associated with the risk of developing non-alcoholic fatty liver disease, with the G allele conferring higher risk.
Salari et al. (2021) studied this question.
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