Key result
The PNPLA3 rs738409 GG genotype was associated with a significantly increased risk of non-alcoholic fatty liver disease compared to the CC genotype (adjusted OR 2.25).
Why the study?
Are genetic variants in the PNPLA3 gene associated with the risk of NAFLD in a Han Chinese population?
Population
1,106 Han Chinese individuals from Fuzhou city, China (553 NAFLD cases, 553 controls)
Comparison
Genetic variants in the PNPLA3 gene vs Reference genotypes / controls without NAFLD
Design
Case-control
Authors
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Supports PNPLA3 genotyping for NAFLD risk stratification in Han Chinese; hypothesis-generating pending prospective validation.
Case-Control (n=1,106)
No
Are genetic variants in the PNPLA3 gene associated with the risk of NAFLD in a Han Chinese population?
Odds Ratio: 2.25 (95% CI 1.46–3.45)
p-value: p=0.001
Genetic variants in the PNPLA3 gene, particularly rs738409 and rs139051, are associated with increased susceptibility to NAFLD in the Han Chinese population, with joint effects observed with metabolic risk factors.
Peng et al. (2012) conducted a case-control in Non-alcoholic fatty liver disease (NAFLD) (n=1,106). PNPLA3 rs738409 GG genotype vs. PNPLA3 rs738409 CC genotype was evaluated on Risk of NAFLD (OR 2.25, 95% CI 1.46-3.45, p=0.001). The PNPLA3 rs738409 GG genotype was associated with a significantly increased risk of non-alcoholic fatty liver disease compared to the CC genotype (adjusted OR 2.25).
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