Why the study?
Does the I148M variant of the PNPLA3 gene influence the susceptibility and histological severity of NAFLD?
Population
Populations assessed for susceptibility and histological severity of nonalcoholic fatty liver disease (NAFLD)
Design
Meta-analysis
Authors
Loading...
May support genotype-informed NAFLD prognostication; reinforces PNPLA3 as modifier in pooled observational data.
Does the I148M variant of the PNPLA3 gene influence the susceptibility and histological severity of NAFLD?
The I148M variant (rs738409) of the PNPLA3 gene is a strong genetic modifier of NAFLD susceptibility and histological severity.
Sookoian et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: