March 4, 2011Open Access

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

Structured PICO

Does the I148M variant of the PNPLA3 gene influence the susceptibility and histological severity of NAFLD?

Population

Populations assessed for susceptibility and histological severity of nonalcoholic fatty liver disease (NAFLD)

Intervention

I148M variant (rs738409) of patatin-like phospholipase domain containing 3 gene (PNPLA3)

Outcome

Susceptibility and histological severity of nonalcoholic fatty liver diseasesurrogate

The I148M variant (rs738409) of the PNPLA3 gene is a strong genetic modifier of NAFLD susceptibility and histological severity.

Abstract

By summarizing the amount of evidence, this study provided unequivocal evidence of rs738409 as a strong modifier of the natural history of NAFLD in different populations around the world.

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

Structured PICO

Abstract

Cite This Study

Also Consider

Also Consider