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April 15, 2026Current ZoologyOpen Access

Epigenetic Mechanisms Linking Hexavalent Chromium Exposure to Pancreatic Cancer Risk: A Systematic Review

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Authors

KHKai HayashiYHYicong HuangKMKenneth R Muir

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Overview

This systematic review evaluates epigenetic effects of chromium exposure linked to pancreatic cancer, suggesting new research avenues.

Key Points

  • The aim is to explore how hexavalent chromium may cause pancreatic cancer through epigenetic mechanisms.
  • Conducted a systematic literature search in EMBASE and PubMed for studies on Cr(VI) exposure.
  • Identified 11 studies that met inclusion criteria focused on epigenetic alterations.
  • Synthesized evidence on effects like DNA methylation and histone modifications.
  • Cr(VI) exposure associated with hypermethylation of tumor suppressor genes, including MLH1 and RAD51.
  • Alterations in histone methylation, particularly increased H3K9me2, were observed.
  • Dysregulation of oncogenic microRNAs such as miR-3940–5p noted.
  • Molecular pathways linked to pancreatic ductal adenocarcinoma (PDAC) influenced by these epigenetic changes.

Cite This Study

Hayashi et al. (2026) studied this question.

synapsesocial.com/papers/69df2bcae4eeef8a2a6b0c36https://doi.org/10.1093/eep/dvag013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations between occupational exposure to chromium (VI) and cancers of the oral cavity, small intestine, pancreas, prostate and urinary bladder: systematic review and meta-analyses2026
  2. 2P-352 HEXAVALENT CHROMIUM CAUSED DNA DAMAGE RESPONSE AND APOPTOSIS VIA THE PI3K/AKT/FOXO1 PATHWAY TRIGGERED BY OXIDATIVE STRESS IN LUNG OF RAT2024
  3. 3Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods2024 · 3 citations
  4. 4O-193 THE SAFECHROM PROJECT - CIRCULATING LUNG-CANCER-RELATED NON-CODING RNAS ARE ASSOCIATED WITH OCCUPATIONAL EXPOSURE TO HEXAVALENT CHROMIUM2024
  5. 5Mechanisms of Hexavalent Chromium-Induced Lung Carcinogenesis: DNA Double-Strand Breaks and DNA Repair Inhibition in a Guinea Pig Model2026