What question did this study set out to answer?

Synthesize evidence from genetic mouse models to define the physiological roles of phosphoinositide 3-kinase signaling and examine how its deregulation contributes to disease.

November 1, 2001Annual Review of Cell and Developmental Biology

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

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Authors

RKRoy KatsoGlaxoSmithKline (United Kingdom)KOKlaus OkkenhaugUniversity of Cambridge KAKhatereh AhmadiShiraz University

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Implication

Narrative review uncovers multifaceted roles of phosphoinositide 3-kinase signaling in animal models, highlighting its therapeutic relevance for cancer and metabolic disease.

Key Points

Synthesize evidence from genetic mouse models to define the physiological roles of phosphoinositide 3-kinase signaling and examine how its deregulation contributes to disease.
Reviewed phenotypic and molecular data from transgenic and knockout mouse models with altered phosphoinositide 3-kinase signaling components.
Evaluated downstream second messenger lipid cascades across diverse physiological processes, including immune function, cell survival, and metabolic regulation.
Phosphoinositide 3-kinase activation generates lipid second messengers that drive cell survival, proliferation, chemotaxis, and glucose homeostasis.
Mouse genetic models reveal distinct, non-redundant roles for specific kinase isoforms during embryonic development and immune cell regulation.
Aberrant signaling within the pathway directly promotes oncogenesis and disrupts normal glucose homeostasis in diabetes.

Cite This Study

Katso et al. (2001) studied this question.

synapsesocial.com/papers/69df2bdcde200760a8614974 https://doi.org/10.1146/annurev.cellbio.17.1.615

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Implication

Narrative review uncovers multifaceted roles of phosphoinositide 3-kinase signaling in animal models, highlighting its therapeutic relevance for cancer and metabolic disease.

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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