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April 15, 2026Open Access

Thyroid Hormone Reference Ranges in Iodine-Deficient Pregnant Women: An Analysis in Foothills of Himalaya, Uttarakhand

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Authors

NYNikku YadavDSDr Ankit SinghASAnita Sharma

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Overview

Cross-sectional analysis establishes TSH levels in pregnant women from iodine-deficient regions, suggesting misclassification risk using standard guidelines.

Key Points

  • This research aims to establish trimester-specific serum TSH reference ranges for pregnant women in iodine-deficient regions of Uttarakhand, India.
  • Cross-sectional observational study conducted in three districts of Uttarakhand.
  • Recruited 544 pregnant women across three trimesters using systematic random sampling.
  • Calculated trimester-specific reference ranges using 2.5th and 97.5th percentiles of TSH and measured urinary iodine excretion.
  • Mean TSH levels increased from 2.18±1.34 to 3.42±1.89 mIU/L across trimesters (p<0.001).
  • Reference ranges for TSH showed significant differences from international standards, with first trimester values of 0.12-4.87 mIU/L.
  • Using international ranges, 50.2% of women would be misclassified as having thyroid dysfunction compared to 30.3% with population-specific ranges.

Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0d9fhttps://doi.org/10.47203/ijch.2026.v38i02.029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global and Indian perspectives on trimester-specific reference intervals for thyroid hormones in pregnant women: a systematic review2026
  2. 2Trimester-Specific Reference Range for Thyroid Function Tests (TFTs) in Normal Pregnant Women at a Tertiary Care Centre2025 · 1 citations
  3. 3Defining Trimester-Specific Reference Intervals for Thyroid Hormones: Insights from a Bulgarian Monocenter Study2024 · 2 citations
  4. 4A Prospective Study to Determine Trimester-Specific Thyroid Function Reference Intervals2025
  5. 5Comparative Analysis of Thyroid Function Tests in Pregnant Females Across Different Gestational Stages and Non-Pregnant Females2025