Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment

Shengjie Wang; Ying Liao; Bowen Yang; Lin Li; Mingrong Xi

doi:10.1039/d5tb02382c

January 1, 2026Journal of Materials Chemistry B

Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment

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Key Points

The research aims to enhance the efficacy of ovarian cancer treatment using co-loaded nanoparticles with piperine and paclitaxel prodrug.
Developed targeted, stimuli-responsive nanoparticle system
Combined piperine and paclitaxel prodrug for treatment
Evaluated anticancer efficacy and systemic toxicity
Demonstrated improved anticancer efficacy compared to single agents
Reduced systemic toxicity observed in preclinical models
Targeted delivery increased drug accumulation at tumor sites

Implication

This preliminary study reports a targeted nanoparticle system enhancing anticancer efficacy in ovarian cancer, suggesting a better treatment approach.

Abstract

Combination chemotherapy incorporating natural products has emerged as an effective strategy to enhance anticancer efficacy while reducing systemic toxicity. Based on this, our study report a targeted, stimuli-responsive nanoparticle system...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69df2c1de4eeef8a2a6b10c1 https://doi.org/10.1039/d5tb02382c

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Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

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