A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Mihyun Park; Juliana Gonçalves; Sandra Deiser; Sebastian Fenzl; Felix Alexander Böhm; Katja Steiger; Susanne Kossatz; Nicole Strittmatter; Angela Casini

doi:10.1039/d6sc00953k

January 1, 2026Chemical ScienceOpen Access

A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

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Key Points

The central aim is to improve mass spectrometry imaging for cancer tissues using a new photocleavable mass-tag.
Developed a photocleavable peptidic Ru(II) mass-tag
Applied targeted DESI and MALDI mass spectrometry techniques
Tested in cancer tissue samples
Improved ionisation efficiency in mass spectrometry
Enhanced spatial resolution in imaging of cancer tissues
Demonstrated feasibility for multi-omics analysis in clinical settings

Implication

Demonstrates enhanced imaging in cancer tissues using a novel mass-tag, suggesting improved analysis in clinical research.

Abstract

Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor ionisation efficiency and...

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Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69df2c1de4eeef8a2a6b1269 https://doi.org/10.1039/d6sc00953k

View Full Paper

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A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Key Points

Implication

Abstract

Discussion

Cite This Study

A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Key Points

Implication

Abstract

Discussion

Cite This Study

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